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. 2023 Feb 23;72(7):2099–2111. doi: 10.1007/s00262-023-03383-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — IO-naïve patients observe greater clinical benefit with a KIR2DL2+/HLA-C1+ and KIR3DL1+/HLA-Bw4+ genotype. Kaplan–Meier curve for PFS (a) compares patients who are KIR2DL2+/HLA-C1+ and KIR3DL1+/HLA-Bw4+ (Group 2, red line) to patients who are not KIR2DL2+/HLA-C1+ and KIR3DL1+/HLA-Bw4+ (Group 1, blue line). Waterfall plots displaying OR and tumor shrinkage (b) compares patients who are KIR2DL2+/HLA-C1+ and KIR3DL1+/HLA-Bw4+ (Group 2, right) with patients who are not KIR2DL2+/HLA-C1+ and KIR3DL1+/HLA-Bw4+ (Group 1, left). CBOR is the confirmed best overall response by RECIST 1.1 criteria; PD, progressive disease (light orange); SD, stable disease (orange); PR, partial response (purple); CR, complete response (light purple). Vertical dotted lines divide the number of patients into thirds, and horizontal dotted lines indicate a + 20% increase and −30% decrease in target lesion size from baseline. The dotted red box outlines the top third of patients, indicating a larger proportion of patients with a positive clinical response in Group 2 (right) than in Group 1 (left)