. Author manuscript; available in PMC: 2024 Jun 1.

Published in final edited form as: Alzheimers Dement. 2022 Dec 14;19(6):2497–2507. doi: 10.1002/alz.12875

Table 1.

Demographic information

	Participants
n	118
Sex (F/M)	57/61
Age (years ± SD)	71.0 ± 8.6
Education (years ± SD)	12.8 ± 4.4
Baseline MMSE (mean ± SD)	26.4 ± 2.4
MMSE slope (mean ± SD)	−1.40 ± 1.92
mPACC slope (mean ± SD) ^§	−1.30 ± 2.67
Cognitive baseline z-score (mean ± SD)	−6.3 ± 3.2
[¹⁸F]RO948 temporal SUVR (mean ± SD)	1.47 ± 0.47
Plasma p-tau217 (ng/ml; mean ± SD)	3.97 ± 5.02
Plasma NfL (ng/ml; mean ± SD)	21.2 ± 24.4
Plasma Aβ42/40 ratio (mean ± SD)	0.21 ± 0.04
CSF p-tau217 (ng/ml; mean ± SD)	278 ± 286
CSF NfL (ng/ml; mean ± SD)	234 ± 182
CSF Aβ42/40 ratio (mean ± SD)	0.07 ± 0.03
Aβ positive (%)	77/118 (65)

CSF = cerebrospinal fluid; F = female; M = male; MMSE = minimental state exam; SD = standard deviation; SUVR = standardized uptake value ratio.

^§

modified PACC measurement used for a sensitivity analysis (n=103).