Figure 1.

Study Design

In this randomized crossover study, 19 patients with hypertriglyceridemia and metabolic syndrome received a high–saturated fat diet and a low–saturated fat diet in a randomized order separated by a 4- to 6-week washout period. Each diet period included 2 study phases: a 4-day diet phase (days 1-4) and a postprandial phase (day 5). Blood was drawn on day 1 after an overnight fast (before diet intervention) and on day 5 fasting (0 hour) and 4 and 6 hours after a test meal, which contained ∼900 kcal and was similar in composition to the respective study diet. White arrows indicate fasting blood draws; closed arrows indicate postprandial blood draws; dashed lines indicate washout period; and the solid line indicates subsequent analyses.