Table 5.

Incidental genetic findings and treatment of patients with inborn errors of immunity.

Case	Gene	Accession	Nucleotide	Amino acid	Zygosity (VAF)	ACMG classification	Novel variants?	Disease (MIM#)	Inheritance	Treatment
Incidental 1	KRAS	NM_004985.3	c.37G>T	p.Gly13Cys	Somatic (19.6%)	Likely pathogenic	Known	RAS-associated autoimmune leukoproliferative disorder (614470)	AD	Sirolimus Rituximab
Incidental 2	ISG15	NM_005101.3	c.379G>T	p.Glu127Ter	Homo	Likely pathogenic	Known	Immunodeficiency 38 (616126)	AR	Conservative care

VAF, variant allele frequency; AD, autosomal dominant; AR, autosomal recessive; HSCT, hematopoietic stem cell transplantation.