TABLE 1.

Studies investigating the acute effects of cannabinoid receptor agonists on male sexual behavior of sexually active rodents.

Species	Drug	Doses and administration route (latency)	Effects on MSB	References
Cannabis preparations
Rat	Hashish resin	8 and 10 mg/kg, i.p.	↓% animals that engaged in copulation	Corcoran et al., 1974
Mouse	Tincture of cannabis (50 mg/ml ethanol). Content: 1.8 mg/ml Δ9-THC; 1.26 CBD; 0.58 CBN and 0.28 CBC	12.5 and 25 mg/kg, i.p. (−45 min)	12.5 mg/kg: ↓ frequency and duration of M and MA. 25 mg/kg: ↓ all sexual behavior responses	Cutler et al., 1975; Cutler and Mackintosh, 1984
Mouse	Hashish extract Content: 40%; Δ9-THC 45% CBD; 9% CBN and 6% other CBs	20 mg/kg, p.o. (−90 min)	↓ All sexual responses (general sedation). No sexual activity	Sieber et al., 1981
Mouse	Hashish extract Content: 40% Δ9-THC; 45% CBD; 9% CBN and 6% other CBs	20 mg/kg, p.o. (−90 min)	General sedation. In this experiment ♀ and ♂ were treated. ↓%M to 0	Frischknecht et al., 1982
Rat	Cannabis flowers	200 and 400 mg, vaporized for 10 min	No changes	Mondino et al., 2019
Phytocannabinoids
Rat	Δ9-THC	2 and 3 mg/kg, i.p.	↑ latencies (ML, EL, and PEI) Dose-dependent ↓ in% of rats that reached E	Merari et al., 1973
Rat	Δ9-THC	0.025 mg/kg, i.p.	↓%M and %E ↓ competition for ♀ in estrus	Uyeno, 1976
Mouse	Δ9-THC	50 and 100 mg/kg, p.o. (−4 h)	Complete suppression of copulation; pre-copulatory behaviors (genital sniffing and grooming) were preserved	Dalterio et al., 1978
Rat	Δ9-THC	5 mg/kg, p.o. (−30 min)	↓%M and %I ↑ ML, IL	Murphy et al., 1994
Synthetic cannabinoids
Rat	HU-210	0.025, 0.05, 0.1 mg/kg, i.p. (−40 min)	0.025 mg/kg: no effect 0.05 mg/kg: ↑ EL 0.1 mg/kg: ↓%M and %I (no E)	Ferrari et al., 2000
Endocannabinoids (eCB)
Rat	AEA	0.5, 1, 2, 4 mg/kg, i.p.	1 mg/kg: ↑ #E/30 min 2 and 4 mg/kg: ↑ ML, ↑ IL; ↑ #I	Martinez-Gonzalez et al., 2004
Rat	AEA	0.1−10 mg/kg, i.p.	0.3 and 1.0 mg/kg: ↓ IL, ↓ EL, ↓ #I, ↑ #E/1 h 3.0 and 10 mg/kg: ↑ IL, ↑ EL, ↓ #E/1 h	Canseco-Alba and Rodríguez-Manzo, 2014; Rodríguez-Manzo and Canseco-Alba, 2015b
Rat	2-AG	0.03−3.0 mg/kg, i.p.	No changes	Canseco-Alba and Rodríguez-Manzo, 2019a

CBs, cannabinoids; Δ9-THC, tetrahydrocannabinol; CBD, cannabidiol; CBN, cannabinol; CBC, cannabichromene; AEA, anandamide; 2-AG, 2-arachidonoylglycerol; i.p., intraperitoneal; p.o., oral. Percentage of animals showing mount attempts: %MA; mounts: %M; intromissions: %I; ejaculation: %E. Sexual parameters: ML, mount latency; IL, intromission latency; EL, ejaculation latency; #M, number of mounts; #I, number of intromissions, #E/time, number of ejaculations observed during a particular period (30 min or 1 h).