TABLE 3.
Studies investigating the effects of repeated administration of cannabinoid receptor agonists on male sexual behavior of sexually active rodents.
| Species | Drug | Doses, route of administration and treatment schedule | Effects on MSB | References |
| Sub-chronic treatment with CBR agonists | ||||
| Mouse | Hashish extract | 20 mg/kg THC, p.o. sub-chronic (3 days, 1X/d) tested daily |
1st day: sedation no sexual activity 2nd day: tolerance to the sedative effects. ↓%AM, %M, and %I but not ≠ from control 3rd day: ↑%AM, %M, and %I |
Sieber et al., 1981 |
| Rat | HU-210 | 0.025−0.1 mg/kg, i.p. sub-chronic (14 days, 1X/d) tests: 7th day and 14th day |
0.025 mg/kg: ↑ trend in ML, IL, and EL; ↓% CS (7th day > 14th day) 0.05 mg/kg: ↑ ML, IL, EL, and PEI and ↓ #M, #I; ↓% CS (7th day > 14th day) 0.1 mg/kg: ↓%CS (7th day > 14th day) |
Ferrari et al., 2000 |
| Rat | HU-210 | 0.1 mg/kg, i.p. sub-chronic (10 days, 1X/d) test: day 11 |
Trend toward ↑ in all temporal parameters. ↓ I and E frequency; test was run after the last administration (−30 min) |
Riebe et al., 2010 |
| Chronic administration of CBR agonists | ||||
| Rat | Δ9-THC Synthetic CME (16% Δ9-THC) | 0.5, 1.5, and 5 mg/kg, p.o. chronic (60 days, 1X/d) test: day 61 |
No differences in mating with any dose or compound evaluated by fertility indices (no specific parameters were evaluated). Administration from PND 40 onward |
Wright et al., 1976 |
| Mouse | Hashish extract (“idem”) | 20 mg/kg, p.o. chronic [3X/week for 12 weeks (36 doses)] tests: 26th or 27th day of treatment |
Decrease in social investigation, specially sexually motivated behavior, whereas non-social activities were significantly increased. The next morning all drug-treated females had vaginal plugs (evidencing sexual interaction) Treatment from weaning onward. (♀ and ♂ treated) |
Frischknecht et al., 1982 |
| Mouse | 50 mg/kg, p.o. chronic [3X/week for 7 weeks (21 doses)] tests: 3rd and 7th week of treatment |
3rd week: ↑ ML and IL 7th week: ↑ ML |
Dalterio, 1980 | |
| Rat | 10 mg/kg, p.o. chronic (30 days, 1X/d) test: day 30th |
Loss of libido (failure to show mounting behavior with a non-receptive female in a 15 min session) | Dhawan and Sharma, 2003 | |
CBR, cannabinoid receptor; CME, crude marijuana extract; PND, postnatal day; i.p., intraperitoneal; p.o., oral. Percentage of animals showing attempted mounts: %AM; mounts: %M; intromissions: %I. Sexual parameters: ML, mount latency; IL, intromission latency; EL, ejaculation latency; PEI, post-ejaculatory interval; CS, copulatory series (i.e., the males resumed copulation after ejaculation).