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. 2023 May 31;14:1207999. doi: 10.3389/fphar.2023.1207999

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Copyright © 2023 Shi, Shi, Liu, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multitarget role of ferulic acid in MTX-mediated hepatotoxicity. Abbreviations: MTX, Methotrexate; GGH, Gamma-Glutamyl Hydrolase; FPGS, Folylpolyglutamate Synthase; MTX-PG, Mtx-polyglutamate; ROS, Reactive Oxygen Species; Keap1, Kelch Like ECH Associated Protein 1; Nrf2, NFE2 Like BZIP Transcription Factor 2; HO-1, Heme Oxygenase 1; Maf, MAF BZIP Transcription Factor; NQO1, NAD(P)H Quinone Dehydrogenase 1.