TABLE 1.

Prostate cancer Mendelian randomization analyses using mLOY SNPs as instrument variables.

Consortium	OR per unit mLOY (IVW method)	OR per unit mLOY (WM method)	I 2 , P heterogeneity	MR-steiger
PRACTICAL	1.09 (1.05–1.13), p = 1.2 × 10−5	1.06 (1.02–1.09), p = 0.0017	72.0%, p = 2.1 × 10−37	TRUE, p < 0.001
Biobank Japan	1.13 (0.88–1.47), p = 0.34	1.15 (0.87–1.54), p = 0.33	54.9%, p = 1.2 × 10−4	TRUE, p < 0.001

IVW, inverse variance weighted; OR, odds ratio; mLOY, mosaic loss of chromosome Y; MR, mendelian randomization; SNPs, single nucleotide polymorphisms; WM, weighted median.