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. 2023 Mar 23;16(6):1021–1038. doi: 10.1111/cts.13508

FIGURE 4.

FIGURE 4

Associations of mean striatal DAT binding with clinical measures in longitudinal analysis. Longitudinal associations of mean striatal DAT binding with clinical measures were shown (a). RBD contributed to a greater decrease in mean striatal DAT binding in PD individuals (b), PD men (c), and PD women (d) respectively. *FDR‐adjusted p < 0.05; and nominal p < 0.05 whereas FDR‐adjusted p ≥ 0.05. #: Unreliable significant results with insufficient sample size in some subgroups. Nominal p values were demonstrated in (b–d). DAT, dopamine transporter; ESS, Epworth Sleepiness Scale; MDS‐UPDRS, Movement Disorder Society‐Sponsored Revision of the Unified Parkinson Disease Rating Scale; PD, Parkinson's disease; PIGD, postural instability and gait difficulty; RBD, rapid‐eye‐movement sleep behavior disorder; SBR, striatal binding ratio; STAI, State–Trait Anxiety Inventory; UPSIT, University of Pennsylvania Smell Identification Test.