TABLE 3.

Clinically validated cocktails involving CYP mediated DDIs.

	Pittsburgh Cocktail 52 , 53	Zhu Cocktail 54	Karolinska Cocktail 55	Blakey Cocktail 58	Cooperstown 5 + 1 Cocktail 56 , 57	Inje Cocktail 59 , 64	Turpault Cocktail 60	Basel Cocktail 61	Geneva Cocktail 62 , 63
Publication date	September 2006	November 2001	June 2003	February 2004	November 2003	November 2007	December 2009	March 2014	September 2016
CYP1A2	Caffeine 100 mg	Caffeine 100 mg	Caffeine 100 mg	Caffeine 100 mg	Caffeine 2 mg/kg	Caffeine 93 mg	Caffeine 100 mg	Caffeine 100 mg	Caffeine 50 mg
CYP2B6								Efavirenz 50 mg	Bupropion 20 mg
CYP2C9	Flurbiprofen 50 mg		Losartan 25 mg	Tolbutamide 250 mg	Warfarin 10 mg	Losartan 30 mg	Warfarin 10 mg	Losartan 12.5 mg	Flurbiprofen 10 mg
CYP2C19	Mephenytoin 100 mg	Mephenytoin 100 mg	Omeprazole 20 mg		Omeprazole 40 mg	Omeprazole 20 mg	Omeprazole 20 mg	Omeprazole 10 mg	Omeprazole 10 mg
CYP2D6	Debrisoquine 10 mg	Metoprolol 100 mg	Debrisoquine 10 mg	Debrisoquine 5 mg	Dextromethorphan 30 mg	Dextromethorphan 30 mg	Metoprolol 100 mg	Metoprolol 12.5 mg	Dextromethorphan 10 mg
CYP3A4	Dapsone 100 mg	Midazolam 7.5 mg	Quinine 250 mg	Midazolam 0.025 mg/kg (i.v.)	Midazolam 0.025 mg/kg (i.v.)	Midazolam 2 mg	Midazolam 0.03 mg/kg	Midazolam 2 mg	Midazolam 1 mg
CYP2E1	Chlorzoxazone 250 mg	Chlorzoxazone 200 mg		Chlorzoxazone 250 mg
Application	85, 86				76, 80, 81, 87, 88, 89, 90, 91, 92, 93	94, 95, 96, 97, 98	82

Note: The dosing route is oral, if not specified.

Abbreviations: DDI, drug‐drug interaction; IV, intravenous.