表3 转移性CRNEC患者肿瘤特异性生存影响因素的回归分析结果（基于倾向评分匹配后病例， n=344）
Table3 Univariate and multivariate analysis of influencing factors for cause-specific survival in patients with metastatic CRNEC (based on patients after propensity score matching, n=344)
|
临床特征 |
单因素分析 |
多因素分析 |
|||||
|
HR |
95% CI |
P值 |
HR |
95% CI |
P 值 |
||
|
年龄>60岁相比≤60岁 |
1.121 |
0.881~1.426 |
0.354 |
— |
— |
— |
|
|
男性相比女性 |
1.306 |
1.027~1.662 |
<0.05 |
1.517 |
1.185~1.942 |
<0.01 |
|
|
婚姻状况 单身相比已婚 |
1.127 |
0.749~1.694 |
0.566 |
1.129 |
0.852~1.497 |
0.398 |
|
|
离异相比在婚 |
1.253 |
0.954~1.647 |
0.105 |
1.174 |
0.752~1.831 |
0.480 |
|
|
肿瘤部位 左半结肠相比右半结肠 |
1.096 |
0.783~1.535 |
0.593 |
0.884 |
0.642~1.217 |
0.449 |
|
|
直肠相比右半结肠 |
1.007 |
0.768~1.320 |
0.962 |
0.628 |
0.452~0.872 |
<0.01 |
|
|
未知相比右半结肠 |
1.623 |
0.792~3.324 |
0.186 |
1.433 |
0.720~2.853 |
0.305 |
|
|
骨转移相比未骨转移 |
1.071 |
0.759~1.511 |
0.696 |
— |
— |
— |
|
|
肝转移相比未肝转移 |
1.145 |
0.824~1.591 |
0.421 |
— |
— |
— |
|
|
肺转移相比未肺转移 |
1.416 |
1.011~1.982 |
<0.05 |
1.346 |
0.917~1.976 |
0.129 |
|
|
手术相比未手术 |
0.731 |
0.572~0.935 |
<0.05 |
— |
— |
— |
|
|
化疗相比未化疗 |
0.512 |
0.382~0.685 |
<0.01 |
— |
— |
— |
|
|
治疗模式 手术相比手术联合化疗 |
2.199 |
1.493~3.240 |
<0.01 |
3.442 |
2.432~4.869 |
<0.01 |
|
|
化疗相比手术联合化疗 |
1.577 |
1.185~2.100 |
<0.01 |
1.776 |
1.305~2.417 |
<0.01 |
|
|
未治疗相比手术联合化疗 |
4.020 |
2.401~6.728 |
<0.01 |
9.442 |
6.098~14.62 |
<0.01 |
—：无相关数据. 单因素分析结果 P值小于0.20的因素纳入多因素分析；因治疗模式与化疗或手术之间不满足变量独立性要求，故纳入治疗模式后未将手术及化疗进一步纳入多因素分析. CRNEC：结直肠神经内分泌癌.