图 1.
HSP70-DNAJ复合物辅助蛋白质折叠的分子伴侣模型
DNAJ家族蛋白与未折叠蛋白质或错误折叠蛋白质(底物)瞬时结合，将底物传递给HSP70. 通过J结构域的介导，DNAJ与HSP70结合并促进其ATP酶活性，从而使得HSP70与底物进行稳定相互作用. 核苷酸交换后，底物从HSP70中释放出来成正确折叠的蛋白质. HSP：热休克蛋白；ATP：腺苷三磷酸；ADP：腺苷二磷酸.
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