Table 2.
Cytotoxic effect of the peptides over MCF-7, HeLa and HEK-293 cell lines, and human erythrocyte.
| IC50 µg mL−1(µM) | |||||
|---|---|---|---|---|---|
| code | MCF-7 | HeLa | fibroblasts | HEK-293 | erythrocytes |
| 26[F] | 79(23) | 24(7) | 121(35) | 203(59) | >200(>58) |
| 26[1-Nal] | 48(14) | 55(16) | 30(9) | 86(25) | >200(>58) |
| 26[hF] | 60(18) | 53(16) | 63(19) | 134(40) | >200(>59) |
| selectivity | |||||
|---|---|---|---|---|---|
| index IC50 no cancerous cells /IC50 MCF-7 | |||||
| (index IC50 no cancerous cells/IC50 HeLa) | |||||
| code | HEK-293 | fibroblasts | erythrocytes | ||
| 26[F] | 2.6 (8.4) | 1.5 (5.0) | >2.5 (>8.3) | ||
| 26[1-Nal] | 1.8 (1.5) | 0.6 (0.5) | >4.1 (>3.6) | ||
| 26[hF] | 2.2 (2.5) | 1.0 (1.2) | >3.3 (>3.7) | ||