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. 2023 Apr 23;10(17):2205915. doi: 10.1002/advs.202205915

Figure 7.

Figure 7

Schema depicting BEST1 positive monocytes/macrophages in circulation and TME. CD14+ monocytes migrate from blood into TME, where VEGF‐A induced the BEST1 expression of TIMs via MEK‐ERK1/2‐ELK1 transcriptional regulation. BEST1 facilitates the secretion of IL‐6 and IL‐8 in TAMs, leading to the promotion of tumor cell proliferation. In addition to the regulation of tumor cells, BEST1 also facilitates the motility of monocytes, which contributes to the migration of monocytes back into circulation.