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. 2023 Apr 11;22(6):e13845. doi: 10.1111/acel.13845

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© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Structural differences between young (left panel) and aged, elderly skin (middle panel). Senescent cells (red) accumulate in aged skin. Right panel: Senescent cells are characterized by upregulation of p21 and p16, secretion of the senescence‐associated secretory phenotype (SASP), increased β‐galactosidase activity, translocation of HMGB1, reduced laminin B1 expression, accumulation of ROS, aberrant of the MAPK‐FOXO3, and modulation of the Nrf2, mTOR and Notch pathways, and DNA damage. DEJ, dermo‐epidermal junction; SC, stratum corneum.