TABLE 4.

Sensitivity analyses in subset with complete data for eight potential confounding variables

	GAF score				Cognitive g‐score a				Somatic burden b
	N in model c	Coefficient	95% CI	p‐value	N in model d	Coefficient	95% CI	p‐value	N in model e	Coefficient	Risk ratio	95% CI	p‐value
BD‐I (vs. BD‐II)	150	−0.86	−5.25 – 3.53	0.699	264	−0.063	−0.32 – 0.20	0.632	166	0.072	1.074	0.78–1.47	0.655
Adjusted analysis 2 f	150	−2.250	−6.49 – 1.99	0.296	264	0.033	−0.24 – 0.31	0.812	166	0.141	1.151	0.80–1.65	0.441

Abbreviations: CI, confidence interval; BD, bipolar disorder; BD‐I, bipolar I disorder; BD‐II, bipolar II disorder; GAF, Global Assessment of Functioning. For every analysis, BD subtype was entered as a fixed predictor variable and study cohort was entered as a random effect.

^a Cognitive g‐score: a continuous z‐score scaling metric with mean = 0, SD = 1, range − 1.00 to +1.00, see text for procedure.

^b Somatic burden: the total number of present physical comorbidities, out of eight disease categories. This outcome variable was only calculated for participants with available data for all of the eight disease categories (N = 513).

^c Generalized Linear Mixed Model using a normal probability distribution with an identity link function.

^d Generalized Linear Mixed Model using a normal probability distribution with an identity link function.

^e Generalized Linear Mixed Model using a Poisson probability distribution with a log link function.

^f Corrected for age, gender, education level, number of affective episodes, late onset, depression severity, history of psychiatric hospitalizations, and anti‐psychotics use.