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Plasma clearance of i.v. injected [3H]ISIS-9388 and [3H]ISIS-3082. Rats were i.v. injected with [3H]ISIS-9388 (open circles) or [3H]ISIS-3082 (closed circles), both at a dose of 1 mg/kg body wt. Blood samples were taken at the indicated times and the radioactivity in the plasma was determined. Values are means ± SEM of four rats.
