Table 2.
Multivariable binomial regression scenarios for fatigue assessed by a VAS 0–10. Models are clustered by country of origin and adjusted for age, sex, and ethnicity
| Sample | Disease status | Group | Predicted VAS-F (mean) |
95% CI | Difference | 95% CI | P |
|---|---|---|---|---|---|---|---|
| All (n = 6.988) | IIM | 4.6 | 4.4 to 4.8 | Ref | |||
| AID | 4.4 | 4.2 to 4.7 | –0.2 | –0.5 to 0.0 | 0.079 | ||
| HC | 2.9 | 2.7 to 3.1 | –1.7 | –1.9 to –1.5 | < 0.001 | ||
| Based on physician assessment | Active + HC (n = 4.519) | IIM | 5.0 | 4.7 to 5.3 | Ref | ||
| AID | 4.9 | 4.7 to 5.2 | –0.1 | –0.5 to 0.4 | 0.810 | ||
| HC | 2.9 | 2.7 to 3.0 | –2.1 | –2.5 to –1.8 | <0.001 | ||
| Inactive + HC (n = 6.453) | IIM | 4.5 | 4.3 to 4.7 | Ref | |||
| AID | 4.3 | 4.0 to 4.5 | –0.3 | –0.5 to 0.0 | 0.052 | ||
| HC | 2.9 | 2.7 to 3.1 | –1.6 | –1.8 to –1.4 | < 0.001 | ||
| Based on patient assessment | Active + HC (n = 6.361) | IIM | 4.8 | 4.6 to 5.0 | Ref | ||
| AID | 4.7 | 4.5 to 4.9 | –0.1 | –0.4 to 0.2 | 0.484 | ||
| HC | 2.9 | 2.7 to 3.1 | –1.9 | –2.1 to –1.7 | < 0.001 | ||
| Inactive + HC (n = 4.879) | IIM | 4.1 | 3.8 to 4.4 | Ref | |||
| AID | 3.8 | 3.6 to 4.0 | –0.3 | –0.6 to 0.0 | 0.033 | ||
| HC | 2.9 | 2.7 to 3.0 | –1.2 | –1.5 to –0.9 | < 0.001 | ||
| Based on steroid dose | Active + HC (n = 4.951) | IIM | 4.9 | 4.7 to 5.0 | Ref | ||
| AID | 4.7 | 4.3 to 5.0 | –0.2 | –0.5 to 0.1 | 0.232 | ||
| HC | 2.9 | 2.7 to 3.0 | –2.0 | –2.2 to –1.7 | < 0.001 | ||
| Inactive + HC (n = 6.021) | IIM | 4.4 | 4.3 to 4.6 | Ref | |||
| AID | 4.3 | 4.0 to 4.5 | –0.2 | –0.5 to 0.1 | 0.275 | ||
| HC | 2.9 | 2.7 to 3.1 | –1.6 | –1.8 to –1.3 | < 0.001 | ||
| General health status | Poor (n = 242) | IIM | 6.8 | 6.5 to 7.1 | Ref | ||
| AID | 7.3 | 7.1 to 7.5 | 0.5 | 0.1 to 0.8 | 0.013 | ||
| HC | 6.8 | 6.0 to 7.6 | 0.0 | –0.8 to 0.7 | 0.957 | ||
| Fair (n = 1.177) | IIM | 5.7 | 5.5 to 6.0 | Ref | |||
| AID | 5.6 | 5.4 to 5.8 | –0.1 | –0.4 to 0.2 | 0.412 | ||
| HC | 4.3 | 3.8 to 4.8 | –1.4 | –1.9 to –0.9 | < 0.001 | ||
| Good (n = 2.510) | IIM | 4.4 | 4.1 to 4.6 | Ref | |||
| AID | 4.3 | 4.1 to 4.5 | –0.1 | –0.4 to 0.3 | 0.679 | ||
| HC | 3.5 | 3.4 to 3.7 | –0.8 | –1.1 to –0.6 | < 0.001 | ||
| Very good (n = 2.142) | IIM | 3.3 | 2.8 to 3.8 | Ref | |||
| AID | 2.8 | 2.5 to 3.2 | –0.5 | –1.2 to 0.2 | 0.184 | ||
| HC | 2.5 | 2.4 to 2.6 | –0.8 | –1.4 to –0.2 | 0.005 | ||
| Excellent (n = 917) | IIM | 2.8 | 1.5 to 4.1 | Ref | |||
| AID | 1.7 | 1.2 to 2.2 | –1.1 | –2.4 to 0.1 | 0.079 | ||
| HC | 1.8 | 1.6 to 2.0 | –1.0 | –2.3 to 0.4 | 0.153 | ||
| Ability to carry out routine activities | Not at all (n = 160) | IIM | 4.2 | 3.6 to 4.9 | Ref | ||
| AID | 4.7 | 3.7 to 5.6 | 0.4 | –0.5 to 1.3 | 0.375 | ||
| HC | 4.1 | 3.3 to 4.8 | –0.2 | –1.4 to 1.0 | 0.760 | ||
| A little (n = 482) | IIM | 6.1 | 5.7 to 6.5 | Ref | |||
| AID | 6.2 | 5.8 to 6.7 | 0.1 | –0.3 to 0.6 | 0.528 | ||
| HC | 4.8 | 4.2 to 5.5 | –1.3 | –2.1 to –0.5 | 0.002 | ||
| Moderately (n = 964) | IIM | 5.3 | 4.9 to 5.7 | Ref | |||
| AID | 5.7 | 5.4 to 5.9 | 0.4 | –0.1 to 0.9 | 0.088 | ||
| HC | 4.6 | 4.2 to 5.0 | –0.7 | –1.1 to –0.3 | 0.001 | ||
| Mostly (n = 1.424) | IIM | 4.6 | 4.2 to 4.9 | Ref | |||
| AID | 4.7 | 4.5 to 4.9 | 0.1 | –0.3 to 0.5 | 0.623 | ||
| HC | 3.8 | 3.5 to 4.0 | –0.8 | –1.2 to –0.3 | 0.001 | ||
| Completely (n = 3.958) | IIM | 3.2 | 2.9 to 3.5 | Ref | |||
| AID | 3.1 | 2.9 to 3.3 | –0.1 | –0.5 to 0.2 | 0.489 | ||
| HC | 2.5 | 2.3 to 2.6 | –0.8 | –1.1 to –0.4 | < 0.001 | ||
VAS visual analog scale, CI confidence interval, HC healthy controls, IIMs idiopathic inflammatory myopathies, Ref reference, SAIDs systemic autoimmune diseases