Table 3.
Multiple scenarios of binomial regression analysis of fatigue, clustered by country of origin and adjusted for age, sex, and ethnicity
| Covariates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Groups | Age | Male | Ethnicity | k | ||||||||
| IIMs | SAIDs | HCs | White | Asian | Hispanic | Others | ||||||
| All | Coefficient | Ref. | –0.05 | –0.47 | 0.00 | –0.17 | Ref. | –0.22 | –0.08 | –0.03 | 1.66 | |
| 95% CI | –0.11 to 0.01 | –0.52 to –0.41 | 0.00 to 0.00 | –0.21 to –0.13 | –0.30 to –0.14 | –0.13 to –0.03 | –0.10 to 0.05 | 1.56 to 1.76 | ||||
| P | 0.082 | < 0.001 | 0.604 | < 0.001 | < 0.001 | 0.003 | 0.478 | < 0.001 | ||||
| Based on physician assessment |
Active + HC |
Coefficient | Ref. | –0.01 | –0.55 | 0.00 | –0.21 | Ref. | –0.19 | –0.09 | –0.05 | 1.78 |
| 95% CI | –0.10 to 0.08 | –0.63 to –0.48 | 0.00 to 0.00 | –0.25 to –0.16 | –0.28 to –0.10 | –0.15 to –0.03 | –0.14 to 0.04 | 1.66 to 1.90 | ||||
| P | 0.810 | < 0.001 | 0.441 | < 0.001 | < 0.001 | 0.005 | 0.279 | < 0.001 | ||||
|
Inactive + HC |
Coefficient | Ref. | –0.06 | –0.44 | 0.00 | –0.17 | Ref. | –0.22 | –0.07 | –0.02 | 1.63 | |
| 95% CI | –0.12 to 0.00 | –0.50 to –0.38 | 0.00 to 0.00 | –0.21 to –0.12 | –0.30 to –0.13 | –0.13 to –0.02 | –0.11 to 0.08 | 1.50 to 1.75 | ||||
| P | 0.054 | < 0.001 | 0.806 | < 0.001 | < 0.001 | 0.010 | 0.723 | < 0.001 | ||||
| Based on patient assessment |
Active + HC |
Coefficient | Ref. | –0.02 | –0.51 | 0.00 | –0.17 | Ref. | –0.22 | –0.08 | –0.02 | 1.72 |
| 95% CI | –0.08 to 0.04 | –0.57 to –0.45 | 0.00 to 0.00 | –0.21 to –0.12 | –0.30 to –0.15 | –0.13 to –0.03 | –0.10 to 0.06 | 1.63 to 1.81 | ||||
| P | 0.484 | < 0.001 | 0.336 | < 0.001 | < 0.001 | 0.002 | 0.543 | < 0.001 | ||||
|
Inactive + HC |
Coefficient | Ref. | –0.08 | –0.36 | 0.00 | –0.21 | Ref. | –0.18 | –0.07 | –0.03 | 1.56 | |
| 95% CI | –0.16 to –0.01 | –0.43 to –0.28 | 0.00 to 0.00 | –0.25 to –0.17 | –0.28 to –0.09 | –0.13 to 0.00 | –0.12 to 0.06 | 1.42 to 1.71 | ||||
| P | 0.030 | < 0.001 | 0.600 | < 0.001 | < 0.001 | 0.037 | 0.539 | < 0.001 | ||||
| Based on glucocorticoid dose |
Active + HC |
Coefficient | Ref. | –0.04 | –0.52 | 0.00 | –0.19 | Ref. | –0.21 | –0.08 | –0.03 | 1.73 |
| 95% CI | –0.11 to 0.03 | –0.59 to –0.46 | 0.00 to 0.00 | –0.23 to –0.15 | –0.30 to –0.12 | –0.14 to –0.02 | –0.13 to 0.06 | 1.61 to 1.85 | ||||
| P | 0.238 | < 0.001 | 0.602 | < 0.001 | < 0.001 | 0.015 | 0.475 | < 0.001 | ||||
|
Inactive + HC |
Coefficient | Ref. | –0.04 | –0.43 | 0.00 | –0.18 | Ref. | –0.21 | –0.09 | –0.03 | 1.63 | |
| 95% CI | –0.11 to 0.03 | –0.50 to –0.36 | 0.00 to 0.00 | –0.23 to –0.14 | –0.30 to –0.11 | –0.14 to –0.03 | –0.11 to 0.05 | 1.51 to 1.76 | ||||
| P | 0.279 | < 0.001 | 0.540 | < 0.001 | < 0.001 | 0.002 | 0.418 | < 0.001 | ||||
|
General health |
Poor | Coefficient | Ref. | 0.07 | 0.00 | 0.00 | 0.00 | Ref. | –0.09 | 0.00 | –0.03 | 1.88 |
| 95% CI | 0.01 to 0.12 | –0.11 to 0.11 | 0.00 to 0.00 | –0.05 to 0.04 | –0.19 to 0.01 | –0.07 to 0.07 | –0.18 to 0.11 | 1.75 to 2.01 | ||||
| P | 0.014 | 0.957 | 0.422 | 0.879 | 0.089 | 0.996 | 0.648 | < 0.001 | ||||
| Fair | Coefficient | Ref. | –0.02 | –0.29 | 0.00 | –0.07 | Ref. | –0.17 | –0.15 | –0.01 | 1.96 | |
| 95% CI | –0.07 to 0.03 | –0.40 to –0.17 | 0.00 to 0.00 | –0.15 to –0.01 | –0.26 to –0.08 | –0.20 to –0.10 | –0.07 to 0.05 | 1.87 to 2.05 | ||||
| P | 0.412 | < 0.001 | < 0.001 | 0.076 | < 0.001 | < 0.001 | 0.778 | < 0.001 | ||||
| Good | Coefficient | Ref. | –0.02 | –0.22 | 0.00 | –0.14 | Ref. | –0.24 | –0.03 | –0.04 | 1.72 | |
| 95% CI | –0.09 to 0.06 | –0.28 to –0.15 | –0.01 to 0.00 | –0.19 to –0.10 | –0.33 to –0.14 | –0.07 to 0.00 | –0.13 to 0.04 | 1.58 to 1.85 | ||||
| P | 0.679 | < 0.001 | 0.004 | < 0.001 | < 0.001 | 0.070 | 0.290 | < 0.001 | ||||
|
Very good |
Coefficient | Ref. | –0.16 | –0.28 | 0.00 | –0.23 | Ref. | –0.23 | –0.07 | –0.18 | 1.49 | |
| 95% CI | –0.40 to 0.07 | –0.45 to –0.10 | –0.01 to 0.00 | –0.33 to –0.14 | –0.37 to –0.09 | –0.14 to –0.01 | –0.29 to –0.06 | 1.24 to 1.74 | ||||
| P | 0.177 | 0.002 | 0.010 | < 0.001 | 0.001 | 0.018 | 0.003 | < 0.001 | ||||
| Excellent | Coefficient | Ref. | –0.52 | –0.43 | –0.01 | –0.03 | Ref | –0.28 | –0.06 | 0.07 | 1.46 | |
| 95% CI | –1.00 to –0.04 | –0.91 to 0.06 | –0.02 to 0.00 | –0.21 to 0.15 | –0.52 to –0.04 | –0.25 to 0.13 | –0.40 to 0.54 | 0.63 to 2.29 | ||||
| P | 0.034 | 0.087 | 0.162 | 0.719 | 0.020 | 0.517 | 0.765 | 0.001 | ||||
|
Routine activities |
Not at all | Coefficient | Ref. | 0.09 | –0.04 | 0.00 | –0.05 | Ref. | –0.72 | –0.41 | –0.66 | 1.61 |
| 95% CI | –0.11 to 0.30 | –0.33 to 0.24 | 0.00 to 0.01 | –0.30 to 0.19 | –1.10 to –0.34 | –0.95 to 0.14 | –1.18 to –0.15 | 1.09 to 2.12 | ||||
| P | 0.366 | 0.761 | 0.340 | 0.670 | < 0.001 | 0.141 | 0.012 | < 0.001 | ||||
| A little | Coefficient | Ref. | 0.02 | –0.24 | 0.00 | –0.12 | Ref. | –0.31 | –0.28 | –0.01 | 2.01 | |
| 95% CI | –0.05 to 0.09 | –0.39 to –0.08 | 0.00 to 0.00 | –0.24 to 0.01 | –0.45 to –0.16 | –0.40 to –0.15 | –0.08 to 0.06 | 1.87 to 2.14 | ||||
| P | 0.527 | 0.003 | 0.085 | 0.068 | < 0.001 | < 0.001 | 0.754 | < 0.001 | ||||
| Moderately | Coefficient | Ref. | 0.07 | –0.14 | 0.00 | –0.09 | Ref | –0.23 | 0.01 | –0.05 | 1.88 | |
| 95% CI | –0.01 to 0.16 | –0.22 to –0.06 | –0.01 to 0.00 | –0.16 to –0.01 | –0.30 to –0.15 | –0.07 to 0.10 | –0.14 to 0.05 | 1.78 to 1.99 | ||||
| P | 0.095 | 0.001 | 0.026 | 0.030 | < 0.001 | 0.759 | 0.335 | < 0.001 | ||||
| Mostly | Coefficient | Ref. | 0.02 | –0.19 | –0.01 | –0.14 | Ref. | –0.21 | –0.01 | –0.10 | 1.84 | |
| 95% CI | –0.07 to 0.12 | –0.30 to –0.08 | –0.01 to 0.00 | –0.19 to –0.10 | –0.29 to –0.12 | –0.07 to 0.05 | –0.20 to 0.01 | 1.68 to 2.00 | ||||
| P | 0.625 | 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.684 | 0.067 | < 0.001 | ||||
| Completely | Coefficient | Ref. | –0.04 | –0.27 | 0.00 | –0.18 | Ref. | –0.27 | –0.02 | –0.03 | 1.47 | |
| 95% CI | –0.15 to 0.07 | –0.38 to –0.16 | –0.01 to 0.00 | –0.23 to –0.13 | –0.41 to 0.13 | –0.08 to 0.05 | –0.15 to 0.09 | 1.27 to 1.67 | ||||
| P | 0.486 | < 0.001 | 0.010 | < 0.001 | < 0.001 | 0.598 | 0.612 | < 0.001 | ||||
SAIDs systemic autoimmune diseases, CI confidence interval, HCs healthy controls, IIMs idiopathic inflammatory myopathies, k constant, Ref reference