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. Author manuscript; available in PMC: 2023 Jun 14.
Published in final edited form as: Cancer Prev Res (Phila). 2017 Dec 15;11(3):143–156. doi: 10.1158/1940-6207.CAPR-17-0264

Fig 4: I-BET 762 prevents lung carcinogenesis in A/J mice.

Fig 4:

Female A/J mice were initiated with vinyl carbamate. The mice were then randomized and fed control diet or IBET 762 (40 mg/kg diet), starting one week after initiation with vinyl carbamate. After 16 weeks of treatment, lungs were harvested to examine tumor burden. A. Representative images of left lungs in each group (10X magnification). A549 lung cancer cells (B), primary VC-1 cells (C) isolated from lung tumors in A/J mice, or lung extracts (D) were treated with different concentrations of I-BET 762 for 48 or 24 hrs, respectively and protein expression analyzed by western blotting. Changes in pERK and PCNA expression in the tumor were confirmed by IHC (E); positive staining is indicated in brown. Representative pictures are shown at 400X magnification, n=5 lungs per group.