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. 2023 May 31;24(6):2766–2776. doi: 10.1021/acs.biomac.3c00178

Figure 2.

Figure 2

In vivo analysis of particle immunogenicity. (a) Immunization schedule; all doses 20 μg VLP; 5 mice per group. (b) Antiparticle IgG titers from mice immunized with indicated particles. Titer curves were analyzed using nonlinear regression curve fitting in Prism, and the titer was calculated as the midpoint of the corresponding curve fit; symbols indicate the mean value for each group ± standard error. (c) IgG subclass distribution from week 5 sera against indicated WT or oligo-modified particles. Symbols indicate the mean value for each group ± standard error. Statistical analysis performed using a one-way ANOVA with Šídák’s multiple comparisons test. **** = p ≤ 0.0001; *** = p ≤ 0.001; ** = p ≤ 0.01; * = p ≤ 0.05.