Table 1. Reports of Oligonucleotide-Protein Nanoparticle Conjugates, Compared to Typical Au–SNAs and Liposomal SNA Preparations^e.

entry	platform	function or description	size (nm)a	#strands	oligo lengthb	DNA density (pmol/cm2)	refs
1	Qβ	GGT repeat	14	100–270	18	6.7–18.2	this work
2	Qβ	GGT repeat	14	100–140	30	6.7–9.2	this work
3	AAV	Cell binding	12.5	≤60c	35	≤5.1	(23)
4	E2	CpG	15	16–21	20	0.9–1.2	(24, 30)
5	MS2	aptamer	14	20–60	41	1.3–4.0	(15, 19)
6	MS2	assembly	14	20	20	1.3	(21)
7	MS2	aptamer	14	54	37	3.6	(20)
8	MS2	CpG	14	38	20	1.8	(22)
9	HBc	CpG	14	≤120d	20	≤8.1	(31)
10	Qβ	GGT repeat	14	20	20	1.3	(13)
11	Qβ	assembly	14	190	18	12.8	(14)
12	catalase	assembly	14 × 8.5 × 7.5	44	18	16.9	(10, 32)
13	β-gal	GGT repeat	9 × 7.5 × 9	30	34	3.7	(11, 26)
14	LacOx	assembly	6	12	35	4.4	(29)
15	AuNP	n.d.e	15	600	25	35.2	(27)
16	lipoNP	T30	16	70	30	4.1	(33)

^aRadius of approximately spherical nanoparticles, or dimensions otherwise.

^bNumber of nucleotides.

^cAssuming 100% of possible sites loaded with oligonucleotide.

^dAssuming 50% of possible sites loaded with oligonucleotide (clickable handle incorporated at dimer interface via genome engineering, so the highest loading is one oligonucleotide per two subunits).

^en.d. = not described.