Table 2.

Comparison results on TICV segmentation. Our methods outperform existing methods in terms of mean DSC and MSD. It is worth noting that FreeSurfer and SPM12 do not generate hard total intracranial segmentation. Therefore, the results of FS and SPM12 on DSC and MSD are N/A. The statistical analyses were conducted between the previous methods and the proposed methods.

Methods	FreeSurfer	SPM12	MV*	NLSS*	nssSLANT	ssSLANT
DSC	N/A	N/A	0.977	0.983	0.987	0.989
MSD	N/A	N/A	0.968	0.743	0.491	0.489

The methods with significant difference (p < 0.05) are marked with ‘*’. All benchmarks are run on brain with skull.