Table 1.
List of hippocampal Sema3D and Sema3A expression levels in neurodegenerative diseases and aging datasets. For each dataset, all subjects were classified according to the severity and phenotypes provided by the original article. The expression levels in all severity groups were normalized to the data of normal subjects in each correspondent dataset. MMSE: Mini-Mental State Examination. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01 using Student's t-test. # p = 0.080, ## p = 0.1658 using one-way ANOVA
Datasets number | Phenotype | Fold change of Sema3 (Phenotype Severity: Low → High) | ||||
---|---|---|---|---|---|---|
GSE11882 | Normal Aging |
age = 20 ~ 49 n = 16 |
age = 50 ~ 79 n = 10 |
age = 80 ~ 100 n = 16 |
||
Sema3D | 1 ± 0.04 | 1.14 ± 0.18 | 2.49 ± 1.19 | |||
Sema3A | 1 ± 0.004 | 1.00 ± 0.01 | 0.91 ± 0.03 | |||
GSE1297 | Alzheimer's Disease (AD) | Normal (Mean age = 85.33 yr; n = 9) | Incipient (Mean age = 91.86 yr; n = 6) | Moderate (Mean age = 83.38 yr; n = 8) | Severe (Mean age = 84.00 yr; n = 7) | |
Sema3D | 1 ± 0.18 | 0.86 ± 0.11 | 1.47 ± 0.31 | 2.16 ± 0.60 * | ||
Sema3A | 1 ± 0.07 | 1.10 ± 0.25 | 1.14 ± 0.09 | 1.26 ± 0.22 | ||
GSE48350 | Alzheimer's Disease (AD) | Normal (Mean age = 62.49 yr, n = 43) | AD (Mean = 83.05 yr, n = 19) | |||
Sema3D | 1 ± 0.06 | 1.57 ± 0.27** | ||||
Sema3A | 1 ± 0.02 | 1.09 ± 0.02 * | ||||
GSE36980 | Alzheimer's Disease (AD) | Normal (Mean age = 77.00 yr, n = 10) | AD (Mean age = 92.86 yr, n = 7) | |||
Sema3D | 1 ± 0.10 | 0.85 ± 0.12 | ||||
Sema3A | 1 ± 0.06 | 0.99 ± 0.10 | ||||
GSE84422 | Clinical Dementia Rating (CDR) | CDR = 0, normal (Mean age = 85.56 yr, n = 9) | CDR = 0.5 ~ 1 (Mean age = 84.58 yr, n = 19) | CDR = 2 ~ 3 (Mean age = 89.41 yr, n = 17) | CDR = 4 ~ 5 (Mean age = 85.20 yr, n = 10) | |
Sema3D | 1 ± 0.01 | 0.97 ± 0.01 | 1.07 ± 0.03 | 1.14 ± 0.03** | ||
Sema3A | 1 ± 0.04 | 0.99 ± 0.03 | 0.97 ± 0.03 | 1.00 ± 0.03 | ||
GSE13162 | FTLD-U | Normal (Median age = 67; n = 2) | Moderate (Median age = 71; n = 8) | Severe (Median age = 64; n = 5) | ||
Sema3D | 1 ± 0.03 | 1.08 ± 0.06 | 1.31 ± 0.11 # | |||
Sema3A | 1 ± 0.29 | 0.96 ± 0.06 | 1.26 ± 0.14 ## |