Table 1.

List of hippocampal Sema3D and Sema3A expression levels in neurodegenerative diseases and aging datasets. For each dataset, all subjects were classified according to the severity and phenotypes provided by the original article. The expression levels in all severity groups were normalized to the data of normal subjects in each correspondent dataset. MMSE: Mini-Mental State Examination. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01 using Student's t-test. # p = 0.080, ## p = 0.1658 using one-way ANOVA

Datasets number	Phenotype		Fold change of Sema3 (Phenotype Severity: Low → High)
GSE11882	Normal Aging		age = 20 ~ 49 n = 16	age = 50 ~ 79 n = 10	age = 80 ~ 100 n = 16
		Sema3D	1 ± 0.04	1.14 ± 0.18	2.49 ± 1.19
		Sema3A	1 ± 0.004	1.00 ± 0.01	0.91 ± 0.03
GSE1297	Alzheimer's Disease (AD)		Normal (Mean age = 85.33 yr; n = 9)	Incipient (Mean age = 91.86 yr; n = 6)	Moderate (Mean age = 83.38 yr; n = 8)	Severe (Mean age = 84.00 yr; n = 7)
		Sema3D	1 ± 0.18	0.86 ± 0.11	1.47 ± 0.31	2.16 ± 0.60 *
		Sema3A	1 ± 0.07	1.10 ± 0.25	1.14 ± 0.09	1.26 ± 0.22
GSE48350	Alzheimer's Disease (AD)		Normal (Mean age = 62.49 yr, n = 43)	AD (Mean = 83.05 yr, n = 19)
		Sema3D	1 ± 0.06	1.57 ± 0.27**
		Sema3A	1 ± 0.02	1.09 ± 0.02 *
GSE36980	Alzheimer's Disease (AD)		Normal (Mean age = 77.00 yr, n = 10)	AD (Mean age = 92.86 yr, n = 7)
		Sema3D	1 ± 0.10	0.85 ± 0.12
		Sema3A	1 ± 0.06	0.99 ± 0.10
GSE84422	Clinical Dementia Rating (CDR)		CDR = 0, normal (Mean age = 85.56 yr, n = 9)	CDR = 0.5 ~ 1 (Mean age = 84.58 yr, n = 19)	CDR = 2 ~ 3 (Mean age = 89.41 yr, n = 17)	CDR = 4 ~ 5 (Mean age = 85.20 yr, n = 10)
		Sema3D	1 ± 0.01	0.97 ± 0.01	1.07 ± 0.03	1.14 ± 0.03**
		Sema3A	1 ± 0.04	0.99 ± 0.03	0.97 ± 0.03	1.00 ± 0.03
GSE13162	FTLD-U		Normal (Median age = 67; n = 2)	Moderate (Median age = 71; n = 8)	Severe (Median age = 64; n = 5)
		Sema3D	1 ± 0.03	1.08 ± 0.06	1.31 ± 0.11 #
		Sema3A	1 ± 0.29	0.96 ± 0.06	1.26 ± 0.14 ##