Table 2.

Sema3D expression levels of the cortex and cerebellum in human Alzheimer's disease datasets. For each dataset, all subjects were classified according to the severity and phenotypes provided by the original article. The expression levels in all severity groups were normalized to the data of normal subjects in each correspondent dataset. CDR: clinical dementia rating; NFT: neurofibrillary tangles. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 using Student's t-test

Datasets number	Phenotype	Tissue	Fold change of Sema3D (Severity: Low → High)
GSE33000	Alzheimer's Disease (AD)	Prefrontal cortex	1.00 ± 0.04 (normal, mean age = 68.6; n = 104)	1.81 ± 0.06*** (Young AD, mean age = 68.6; n = 70)	2.07 ± 0.07*** (Old AD, mean age = 86.7; n = 206)
GSE44770	Alzheimer's Disease (AD)	Prefrontal cortex	1.00 ± 0.03 (normal, mean age = 62.6; n = 62)	2.01 ± 0.08*** (Young AD, mean age = 62.6; n = 14)	2.28 ± 0.08*** (Old AD, mean age = 82.99; n = 94)
GSE44768	Alzheimer's Disease (AD)	Cerebellum	1 ± 0.04 (normal; n = 81)	1.35 ± 0.06*** (AD; n = 108)
GSE44771	Alzheimer's Disease (AD)	Visual cortex	1 ± 0.05 (normal; n = 76)	2.05 ± 0.08*** (AD; n = 119)
GSE185909	Alzheimer's Disease (AD)	Prefrontal cortex	1 ± 0.97 (normal; n = 7)	1.13 ± 1.17 (MCI; n = 10)	1.41 ± 0.85 (AD; n = 17)
GSE131617	Alzheimer's Disease (AD)	frontal cortex	1.00 ± 0.39 (NFT 0, normal; n = 13)	1.04 ± 0.56 (NFT I-II; n = 20)	1.03 ± 0.48 (NFT III-VI; n = 19)	1.03 ± 0.47 (NFT V-VI; n = 19)
GSE84422	Alzheimer's Disease (AD)	frontal cortex	1.00 ± 0.15 (CDR = 0, normal; n = 11)	0.99 ± 0.13 (CDR = 0.5 ~ 1; n = 17)	1.03 ± 0.22 (CDR = 2 ~ 3; n = 23)	1.03 ± 0.47 (NFT V-VI; n = 19)