Date	Event	Description
14 June 2023	New citation required but conclusions have not changed	A new author has joined the review team (Sherie Smith). Seven new trials have been included at this update (353 participants). Four trials were added to the existing comparison of hypertonic saline 3% to 7% versus isotonic saline in stable lung disease (Amin 2016; Donaldson 2020; PRESIS 2019; SHIP 2019). We have included two new comparisons: hypertonic saline compared to xylitol (two trials, 90 participants; NCT01355796; Singh 2020) and 7% hypertonic saline compared to 3% hypertonic saline (one trial, 30 participants; Gupta 2012). Despite these changes, our conclusions remain the same.
14 June 2023	New search has been performed	A search of the Cochrane Cystic Fibrosis and Genetic Disorders Review Group's Cystic Fibrosis Trials Register identified 23 new references potentially eligible for inclusion in this updated review. Included studies Two additional references were to two already included studies (Gupta 2012; Mainz 2015). Five studies previously listed as awaiting classification have been included at this update (Amin 2010; Donaldson 2020; PRESIS 2019; SHIP 2019; Singh 2020) with nine additional references added to four of these: two references were added to the Donaldson study (Donaldson 2020); four references were added to the PRESIS study (PRESIS 2019); two references were added to the SHIP study (SHIP 2019); and one reference was added to the Singh study (Singh 2020).  On further investigation a trial registry entry (NCT02276898) previously listed as ongoing was identified as the protocol for an included study (Amin 2016). Excluded studies Two additional references were added to two already excluded studies (Aquino 2012; San Miguel‐Pagola 2016). Two additional references were added to two studies previously listed as awaiting classification and now excluded at this update (Brown 2010; Corcoran 2017).  Six additional references were added to the SHIP‐CT study previously listed as ongoing and moved to excluded studies at this update (Tiddens 2022). Studies awaiting classification One new study (two references) is listed as awaiting classification (SIMPLIFY 2022) Trial Registry searches Seven trials were identified from the trial registry searches; four of these were excluded (ACTRN12619001681145; ACTRN12621000855820; IRCT20191112045413N2; IRCT20201017049055N1); one has been listed as ongoing (ISRCTN14081521), one entry is listed under the study already listed as awaiting classification (SIMPLIFY 2022) and one was deleted immediately as it was not relevant.