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. 2023 May 30;120(23):e2216908120. doi: 10.1073/pnas.2216908120

Fig. 7.

Fig. 7.

Tuft cells are required to induce AMP expression changes in response to bacterial dysbiosis in the distal SI. (A) Ileal tuft cell frequency in control or PEG-treated (12 d) Pou2f3+/− mice as determined by flow cytometry (n = 9 to 17 mice per group). (B) Expression of representative AMP genes determined by qRT-PCR in the ileal epithelial fraction of control or PEG-treated Pou2f3+/− and Pou2f3−/− mice (n = 5 to 17 mice per group). Relative expression normalized to Gapdh. Center values = median; error bars = IQR. Significance was determined using the Mann–Whitney U test. ns = no significance, *P < 0.05, **P < 0.01, ***P < 0.001.