Fig. 2.

Loss of Fkbp5 leads to cell- and sex-specific effects on behavior that are unique to certain behavior domains. No significant changes in locomotion (A) as measured by a 15-min Open Field test could be observed as a result of loss of Fkbp5 in older aged mice. However, loss of Fkbp5 in glutamatergic neurons leads to (B) an anxiety-like phenotype on the EPM, where loss in GABAergic neurons leads to anxiolytic behavior. These effects on anxiety are solely observed in female mice. On the contrary, cognitive behavior under stressful conditions is mainly affected in older aged male mice (C). Where loss of Fkbp5 in glutamatergic neurons reduces the memory of an adverse environment, a reduction in Fkbp5 in GABAergic neurons enhances the memory of an aversive event. Error bars represent mean ± SEM.*P < 0.05, **P <0.01, ***P < 0.001.