Table 3.
Ferroptosis and Mitochondrial Fission, Fusion, Mitophagy
| Group | Mitochondrion | Ferroptosis | Mechanism | Related articles | Ref. |
|---|---|---|---|---|---|
| Ferroptosis and mitochondrial fission | DRP1 Fis1 Mff |
NRF2, ROS, lipid peroxidation | Vitamin D3/ DRP1, Fis1/ROS/ lipid peroxidation | Vitamin D3 attenuates cisplatin-induced intestinal injury by inhibiting ferroptosis, oxidative stress, and ROS-mediated excessive mitochondrial fission. | 84 |
| Erastin/ROS/DRP1, Fis1, MFF/ mitophagy (PINK1, Parkin) | Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis. | 85 | |||
| NRF2/ proteasomal genes /DRP1 | The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1 | 83 | |||
| CA9/ Mitochondrial fission | Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia. | 86 | |||
| Mitochondrial fission/p53/SLC7A11/GPX4 | SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling. | 87 | |||
| Ferroptosis and mitochondrial fusion | MFN1 MFN2 OPA1 |
NRF2, ROS, lipid peroxidation | NRF2/MFN2 | Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice | 88 |
| Erastin /STING1/ MFN1/2/ROS/ lipid peroxidation/ferroptosis | STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion. | 89 | |||
| Selenium/ MFN1/ROS/ferroptosis | Selenium Alleviates Cerebral Ischemia/Reperfusion Injury by Regulating Oxidative Stress, Mitochondrial Fusion and Ferroptosis. | 90 | |||
| QSYQ/ MFN2, OPA1 | QiShenYiQi dripping pill alleviates myocardial ischemia-induced ferroptosis via improving mitochondrial dynamical homeostasis and biogenesis. | 91 | |||
| Ferroptosis and mitophagy | PINK1 Parkin FUNDC1 |
System Xc-, GPX4, ACSL4, NRF2, ROS, Fe2+, NCOA4, lipid peroxidation |
Mitophagy/dysfunctional mitochondria/ROS/ferroptosis | Oxidative Stress and Ischemia/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants. | 96 |
| Myoferlin/ mitophagy/ System Xc-/GPX4/ROS | Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. | 98 | |||
| Dynamic O-GlcNAcylation/ ferritinophagy (NCOA4), mitophagy/ Fe2+/ROS/ lipid peroxidation/ ferroptosis | Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis. | 97 | |||
| NRF2/ mitophagy (P62-dependent, PINK1/Parkin-independent) | PMI: a DeltaPsim independent pharmacological regulator of mitophagy. | 33 | |||
| High Glucose/TXNIP/ ferritinophagy (NCOA4), mitophagy/ Fe2+, GSH, GPX4/ROS/ lipid peroxidation/ ferroptosis | Mitophagy, Ferritinophagy and Ferroptosis in Retinal Pigment Epithelial Cells Under High Glucose Conditions: Implications for Diabetic Retinopathy and Age-Related Retinal Diseases. | 101 | |||
| FUNDC1/JNK/ lipid peroxidation/ferroptosis | Ablation of FUNDC1-dependent mitophagy renders myocardium resistant to paraquat-induced ferroptosis and contractile dysfunction. | 99 | |||
| FUNDC1/ACSL4 | FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis. | 100 | |||
| Erastin/ROS/DRP1, Fis1, MFF/ mitophagy (PINK1/Parkin) | Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis. | 85 | |||
| Mitochondrial complex I/ mitophagy (PINK1)/ROS/ferropsosis | Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. | 102 | |||
| Mitophagy/CISD3/ lipid peroxidation | CISD3 inhibition drives cystine-deprivation induced ferroptosis. Cell Death Dis | 103 | |||
| Mitochondrial Ferritin Deficiency / Fe2+/ROS / mitophagy (PINK1/Parkin)/ferroptosis | Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis. | 104 |
ACSL4 Acyl-CoA synthetase long-chain family member 4; DRP1: dynamin-related protein 1; Fis1: mitochondrial fission protein 1; GPX4: glutathione peroxidase 4; GSH: glutathione; HIF-1 hypoxia-inducible factor 1; Mff: mitochondrial fission factor; MFN1: mitochondrial fusion protein 1; MFN2: mitochondrial fusion protein 2; NCOA4: nuclear receptor coactivator 4; NRF2: nuclear factor red lineage 2 related factor 2; NSCLC: non-small cell lung cancer; OPA1: optic atrophy 1 protein; PINK1: PTEN-induced kinase 1; PUFAs: polyunsaturated fatty acids; ROS: reactive oxygen species