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. 2023 May 11;19(9):2695–2710. doi: 10.7150/ijbs.80735

Figure 1.

Figure 1

Effects of siHDAC9 on cell death and expression of ferroptotic genes in SH-SY5Y cells after OGD/Rx. A, HDAC9 protein expression at 48h or 72h after OGD/Rx. (n = 5). *, p ≤ 0.05 versus control under normoxic conditions (CTL); #, p ≤ 0.05 versus 48h after OGD/Rx. B-E, Effects of siHDAC9 or scrambled siRNA on gene expression of TfR1 (B), Fpn1 (C), Ft (D) and GPX4 (E) after OGD/Rx 72h. (n = 3); *, p ≤ 0.05 versus control (CTL); #, p ≤ 0.05 versus siCTL+. F-G, Viability measured with MTT assay (F) and cell death measured as LDH release (G) in cells treated with siRNA for HDAC9 or scrambled at 72h after OGD/Rx. (n = 4). *, p ≤ 0.05 versus control (CTL); #, p ≤ 0.05 versus siCTL. Bars represent mean ± SD.