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. 2023 Jun 4;19(9):2934–2956. doi: 10.7150/ijbs.81961

Figure 6.

Figure 6

Colchicine or AG-1478 reduces the inflammatory cell infiltration and fibrosis in atrial tissues of LPS-stimulated mice. A-J. Immunohistochemical staining and quantification of CD3+ T lymphocytes, CD20+ B lymphocytes, F4/80+ macrophages, mast cells and EGFR positive cells in atrial tissues of the control group, LPS group, LPS + colchicine group, and LPS + AG-1478 group. n= 5 mice. K. Representative images of HE and Masson staining on the atrial sections of the control group, LPS group, LPS + colchicine group, and LPS + AG-1478 group. Scale bar, 100 μm. n= 4 mice. L. Scatter dot plot to compare the percentage of interstitial fibrosis area in atrial tissues of the control group, LPS group, LPS + colchicine group, and LPS + AG-1478 group. n= 4 mice. Three fields of views were measured for each mouse.