Table 1.

Summary of ferroptosis inducers and inhibitors

Classification	Reagents	Mechanism	Reference
Ferroptosis Inducers	Erastin	Inhibition of system Xc- and VDAC2/3	10
	Sulphasalazine	Inhibition of system Xc-	10, 48
	Sorafenib	Inhibition of system Xc- and Nrf2	49, 50
	Glutamate	Inhibition of system Xc- and Cys deprivation	51
	RSL3	GPX4 inactivation	32
	Solasonine	GPX4 inactivation	52
	Altretamine	GPX4 inactivation and promotion of ROS	53
	FINO2	GPX4 inactivation and oxidation of unstable iron	54
	FIN56	GPX4 inactivation and CoQ10 deletion	55
	BSO	GSH deletion	32
	DPI2	GSH deletion	32
	Cisplatin	GSH deletion and GPX4 inactivation	56
	Artesunate	Degradation of ferritin and increased cellular iron	57
	iFSP	Inhibition of FSP1	34
	Brequinar	Inhibition of DHODH	36
Ferroptosis Inhibitors	Ferrostatin-1	Inhibition of lipid peroxidation	58
	Liproxstatin-1	Inhibition of lipid peroxidation	33
	Necrostatin-1	Inhibition of lipid peroxidation	33, 59
	SRS 16-86	Inhibition of lipid peroxidation	60
	SRS 11-92	Inhibition of lipid peroxidation	58
	Nuciferine	Inhibition of lipid peroxidation	61
	TEMPO	Elimination of ROS	62
	Phenothiazine	Elimination of ROS	63
	Phenoxazine	Elimination of ROS	63
	Diarylamine	Elimination of ROS	63
	Vitamin E	Elimination of ROS and inactivation of LOXs	27, 64
	NDGA	Inactivation of LOXs	65
	Zileuoton	Inactivation of LOXs	66
	Baicalein	Inactivation of LOXs and ACSL4	65, 67
	Thiazolidinedione	Inactivation of ACSL4	68
	Dexrazoxane	Depletion of cellular iron	69
	Deferoxamine	Depletion of cellular iron	69
	Deferiprone	Depletion of cellular iron	70
	β-Mercaptoethanol	Increased cysteine intake	71
	Vitamin K	Activation of FSP1	72
	Curcumin	Activation of Nrf2	73
	Quercetin	Activation of Nrf2 and elimination of ROS	74, 75
	MCTR1	Activation of Nrf2	76
	Irisin	Activation of Nrf2	77