Comparison 3. Efficacy and safety of IVT pegcetacoplan 4‐weekly versus sham for geographic atrophy (GA).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 GA lesion size change at 1 year (mm2)	3	967	Mean Difference (IV, Random, 95% CI)	‐0.38 [‐0.57, ‐0.19]
3.2 Extrafoveal GA lesion size change at 1 year (mm2)	2	291	Mean Difference (IV, Fixed, 95% CI)	‐0.67 [‐0.98, ‐0.36]
3.3 Safety: Development of MNV or exudative AMD at 1 year	2	1003	Risk Ratio (M‐H, Random, 95% CI)	4.47 [0.41, 48.98]
3.4 Development of endophthalmitis at 1 year	3	1003	Risk Ratio (M‐H, Random, 95% CI)	3.79 [0.42, 34.05]