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. 2023 Jun 14;11(6):e898. doi: 10.1002/iid3.898

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© 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Interleukin‐38 (IL‐38) inhibited cardiomyocyte apoptosis in vivo. (A) Representative images of terminal deoxynucleotidyl transferase dUTP nick‐end labeling (TUNEL)‐stained heart sections from different experimental groups 1 day after ischemia/reperfusion (I/R). TUNEL (green) and 4′,6‐diamidino‐2‐phenylindole (blue) staining of nuclei in apoptotic cardiomyocytes (red) in the peri‐infarct zone. Scar bar:100 μm; magnification: ×400. (B) Quantitative analysis of the percentages of TUNEL‐positive nuclei (each group n = 6). (C) Real‐time polymerase chain reaction determined messenger RNA expression levels of Bax and Bcl‐2 in the in infarct heart on Day 1 in I/R. The results were also expressed as the ratio of Bax/Bcl‐2 (n = 6). *p < .05; **p < .01.