Figure 4.

Ungapped alignment of telomere 3′ ends. (A) Telomeres from a clonal population of wild-type cells show a divergence of the TG_1–3 repeat sequence starting 40–100 bp from the 3′ end. (B) In yku70-Δ cells, telomeric repeat sequences diverge to approximately the same extent as in wild-type cells. (C) Divergence of the 3′ end repeat sequences is lost completely in tlc1-Δ cells (shown are the shortest telomeres recovered; distal repeat divergence was also undetectable in earlier generations).