Table 2.
Index DMPs identified in the discovery dataset and replicated in the replication group.
| CpG | Position | Discovery (n = 114) | Replication (n = 235) | Combined p-value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr | Position | Gene | Feature | Mean (treated) | Mean (untreated) | Delta Beta | P-Value | Mean (treated) | Mean (untreated) | Delta Beta | P-value | Combined p-value | |
| cg01028142 | 2 | 7004578 | CMPK2 | Body | 0.77 | 0.86 | −0.09 | 8.73E-14 | 0.75 | 0.83 | −0.08 | 3.79E-15 | 3.31E-28 |
| cg24678928 | 4 | 169240829 | DDX60 | TSS1500 | 0.70 | 0.80 | −0.10 | 1.52E-09 | 0.70 | 0.79 | −0.09 | 9.35E-12 | 1.42E-20 |
| cg13452062 | 1 | 79088559 | IFI44L | 5’UTR | 0.50 | 0.77 | −0.27 | 2.06E-10 | 0.53 | 0.77 | −0.23 | 2.11E-13 | 4.34E-23 |
| cg08888522 | 2 | 163172908 | IFIH1 | Body | 0.81 | 0.89 | −0.07 | 1.60E-10 | 0.83 | 0.88 | −0.05 | 4.29E-10 | 6.86E-20 |
| cg05552874 | 10 | 91153143 | IFIT1 | Body | 0.46 | 0.57 | −0.11 | 3.00E-10 | 0.49 | 0.54 | −0.05 | 3.08E-05 | 9.25E-15 |
| cg06188083 | 10 | 91093005 | IFIT3 | Body | 0.36 | 0.45 | −0.08 | 3.39E-08 | 0.35 | 0.43 | −0.08 | 4.13E-11 | 1.40E-18 |
| cg26312951 | 21 | 42797847 | MX1 | TSS200;5’UTR | 0.20 | 0.28 | −0.08 | 1.25E-10 | 0.19 | 0.27 | −0.08 | 2.50E-13 | 3.12E-23 |
| cg26505274 | 12 | 121474114 | OASL | Body | 0.72 | 0.63 | 0.09 | 2.45E-10 | 0.69 | 0.60 | 0.09 | 2.33E-10 | 5.71E-20 |
| cg22930808 | 3 | 122281881 | PARP9 | 5’UTR | 0.49 | 0.61 | −0.12 | 6.06E-09 | 0.48 | 0.58 | −0.10 | 2.81E-10 | 1.70E-18 |
| cg06981309 | 3 | 146260954 | PLSCR1 | 5’UTR | 0.29 | 0.38 | −0.09 | 3.43E-09 | 0.30 | 0.34 | −0.04 | 2.20E-05 | 7.55E-14 |
| cg10549986 | 2 | 7018153 | RSAD2 | 1stExon | 0.11 | 0.18 | −0.07 | 4.17E-08 | 0.14 | 0.20 | −0.06 | 1.88E-09 | 7.83E-17 |
Index DMPs were used to construct the MTS.