|
Severe PPM
|
6.0 (38)
|
3.6 (12)
|
8.8 (26)
|
0.22 (0.11-0.44)
|
<0.001
|
0.25 (0.10-0.60)
|
0.002
|
|
Severe PPM (non-BMI-adjusted)
|
8.6 (54)
|
4.2 (14)
|
13.5 (40)
|
0.28 (0.15-0.53)
|
<0.001
|
0.36 (0.16-0.82)
|
0.015
|
|
More than mild PVL
|
9.4 (107)
|
10.1 (73)
|
8.3 (34)
|
1.24 (0.81-1.90)
|
0.319
|
0.98 (0.60-1.60)
|
0.944
|
|
All-cause mortality
|
10.3 (129)
|
9.4 (76)
|
11.9 (53)
|
1.10 (0.77-1.56)^
|
0.604
|
1.34 (0.81-2.23)^
|
0.255
|
|
Characteristic
|
Overall (n=1,378)
|
Self-expanding valve (n=1,092)
|
Balloon-expandable valve (n=286)
|
Unadjusted OR/HR (95% CI)*
|
p-value
|
IPTW-adjusted HR/OR (95% CI)†
|
p-value
|
|
Severe PPM
|
6.0 (38)
|
4.6 (19)
|
8.6 (19)
|
0.25 (0.13-0.48)
|
<0.001
|
0.40 (0.18-0.91)
|
0.029
|
|
Severe PPM (non-BMI-adjusted)
|
8.6 (54)
|
5.6 (23)
|
14.2 (31)
|
0.36 (0.20-0.63)
|
<0.001
|
0.66 (0.33-1.33)
|
0.246
|
|
More than mild PVL
|
9.4 (107)
|
11.6 (100)
|
2.6 (7)
|
4.87 (2.24-10.6)
|
<0.001
|
4.85 (1.70-13.9)
|
0.003
|
|
All-cause mortality
|
10.3 (129)
|
9.8 (95)
|
12.3 (34)
|
1.26 (0.85-1.87)^
|
0.258
|
1.59 (0.90-2.81)^
|
0.109
|
|
Results reported as % (number of events), HR, OR, and 95% CI. Comparisons are SAV versus IAV and SEV versus BEV. *Generated with univariable logistic/Cox regression analysis. †Generated with logistic/Cox regression modelling after IPTW adjustment. ^HR was analysed via Cox regression analysis for the outcome all-cause mortality (at a median follow-up of 377 days). All other outcomes had OR assessed via logistic regression analysis. The values in bold represent differences between groups with p<0.100. AV: aortic valve; BEV: balloon-expandable valve; BMI: body mass index; CI: confidence interval; HR: hazard ratio; IAV: intra-annular valve; IPTW: inverse probability of treatment weighting; OR: odds ratio; PPM: prosthesis-patient mismatch; PVL: paravalvular leak; SAV: supra-annular valve; SEV: self-expanding valve
|
