Figure 1.

Excision of FapyGua by wt-hOgg1, hOgg1-Gln⁴⁶ and hOgg1-His¹⁵⁴ as a function of the enzyme amount. DNA γ-irradiated under N₂O (100 µg) was used as a substrate. The incubation time was 30 min at 37°C. The amounts given on the y-axis represent those found in the supernatant fractions. Closed squares, wt-hOgg1; open circles, hOgg1-Gln⁴⁶; closed circles, hOgg1-His¹⁵⁴.