Table 1.

Epidemiological and clinical data.

Case number	Gender	Age (years)	Symptoms and signs	Laboratory tests alterations	Time to diagnosis (months)
1	M	62	Proximal myopathy, Cushingoid phenotype, weight gain, osteoporosis/fractures, asthenia, hyperpigmentation, oedema of limbs, unusual infections, constitutional syndrome	↓ K; ↑ALP, GGT, ALT, AST; ↑leucocytes; DM	2
2	M	29	Facial plethora, proximal myopathy, striae, Cushingoid phenotype, weight gain, osteoporosis/fractures, asthenia, oedema of limbs, hypertension, nephrolithiasis, psychiatric disorders, gynecomastia	None	24
3	F	40	Capillary fragility, Cushingoid phenotype, weight gain, osteoporosis/fractures, asthenia, hypertension, menstrual disorders	↓ K	12
4	M	68	Cushingoid phenotype, weight gain, oedema of limbs, hypertension, gynecomastia	↓ K; DM; DL.	2
5	M	31	Proximal myopathy, striae, Cushingoid phenotype, weight gain, asthenia, hypertension	↓ K; ↑ ALP, GGT, ALT, AST; DM	12
6	M	50	Facial plethora, proximal myopathy, capillary fragility, Cushingoid phenotype, weight gain, asthenia, oedema of limbs, hypertension, psychiatric disorders, gynecomastia	↓ K; ↑ALP, GGT, ALT, AST; ↑leucocytes; DM; DL	2
7	F	77	Proximal myopathy, asthenia, oedema of limbs, hypertension, psychiatric disorders	↓ K; ↑leucocytes; DM; DL	2
8	M	61	Facial plethora, proximal myopathy, capillary fragility, asthenia, oedema of limbs, hypertension	↓ K; ↑leucocytes; DM; DL; ↑ALT, AST	1
9	M	76	Proximal myopathy, capillary fragility, osteoporosis/fractures, hyperpigmentation, oedema of limbs, hypertension, nephrolithiasis, unusual infections, deep vein thrombosis	↓ K; ↑leucocytes; DM; DL	4
10	F	61	Proximal myopathy, capillary fragility, weight gain, asthenia, hypertension, unusual infections	↓ K; ↑ALP, GGT, ALT, AST; ↑leucocytes; DM	1
11	F	61	Capillary fragility, Cushingoid phenotype, oedema of limbs, hypertension, virilisation	↓ K; ↑leucocytes	1
12	M	66	Capillary fragility, asthenia, oedema of limbs, hypertension	↓ K; ↑leucocytes; DM	4

ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate transaminase; DL, dyslipidemia; DM, diabetes mellitus; F, female; GGT, gamma-glutamyl transferase; K, serum potassium; M, male.