Table 2.

Hormonal parameters.

Case number	PC (µg/dL)	ACTH (pg/mL)	LNSC (µg/dL)	UFC (µg/24 h)	1-mg DST (µg/dL)	8-mg DST ΔPCa %	CRH stimulation testb		BIPSS (ACTH C/P gradient)c		BIPSS (PRL C/P basal gradient)	Other hormones and biomarkers
							ΔACTH, %	ΔPC, %	Basal	After CRH		17OH, µg/L	ADS, µg/dL	5HIIA, mg/24h	CgA, ng/mL
Normal range	5–25	5-60	0.0–0.2	20–120	PC < 1.8							0.25–3.90	0.30–2.60	7–8.2	19–98
1	40.5	263	-	4470	37.2	-	+43.91	+14.04	1.78	0.97	29.5/12.8 = 2.30	8.26	>10	82.7
2	20	132.6	0.296	1229	-	−1	+45.02	+8.83	1.39	1.73	11.8/10.8 = 1.09	5.86		9.6
3	49	75	1.21	838	-	-	+19.41	+11.5	1.39	1.56	5.5/8.1 = 0.67		5.26		293
4	27.8	139.5	0.063	2227	28.4	+0.6	+10	+18.5	1.02	1.42	-		>10
5	52.1	226	-	6246	-	-	−20		-		-				-
6	79.6	271.6	-	1500	86.1	-	-		-		-				3302
7	98.1	248.2	-	1860	34.4	−18.89	-		-		-		>10		↑
8	47.1	162.9	-	11,876	54.3	-	-		-		-				89
9	42.4	274.8	1.12	1395	43.3	−36.55	-		-		-				186
10	62.8	120.1	0.05	2552	27.5	-	-		-		-				-
11	49.9	84.6	2.12	-	45.7	−8.61	-		-		-				-
12	97.1	236.7	-	1920	79.4	−13.18	-		-		-				-

^aSuppression was considered if ΔPC < −50%; ^bStimulationwas positive for Cushing’s disease if ΔACTH > 50% and ΔPC >20%; ^cACTH C/P gradient basal >2 or after stimulation by CRH >3 was positive for Cushing’s disease.

1-mg DST, 1-mg (low-dose) dexamethasone suppression test; 5HIIA, 5 hydroxyindolacetic acid; 8-mg DST, 8-mg (high-dose) dexamethasone suppression test; 17OHP, 17 hydroxyprogesterone; ACTH, adrenocorticotropic hormone; BIPSS, bilateral inferior petrosal sinus sampling; C/P, central/peripheral; CgA, chromogranin A; CRH, corticotropin-releasing hormone; LNSC, late-night salivary cortisol; PC, plasma cortisol; PRL, prolactin; UFC, 24-h urinary free cortisol.