Table 2.

Hepatocellular Adenoma Histology, Size, and Growth by Hormonal Exposure in Females with HCAs from 2003–2021 (n = 34)

Characteristic	No hormone exposure (n = 19)	Estrogen exposure (n = 7)	Progestin-only exposure (n = 8)	Progestin-only vs no hormone exposure p-value	Progestin-only vs estrogen exposure p-value
Type of HCA, n (%)
Beta catenin-activated	1 (5%)	0 (0%)	0 (0%)	1.00
Inflammatory	5 (26%)	3 (43%)	1 (13%)	0.63	0.28
HNF-1 alpha inactivated	3 (l6%)	0 (0%)	2 (25%)	0.62	0.47
Unclassified	3 (l6%)	1 (14%)	2 (25%)	0.62	1.00
Unspecified	2 (l1%)	0 (0%)	0 (0%)	1.00	-
Adenomatosis (≥ 10 HCAs), n (%)	1 (5%)	0 (0%)	2 (25%)	0.20	0.47
Largest baseline adenoma, median cm (IQR)	4.0 (2.2 – 4.9)	3.3 (1.7 – 3.8)	3.3 (2.8 – 3.7)	0.49	0.98
Number of imaging reports, median number (IQR)	4 (2 – 6.5)	3 (2 – 3.5)	3.5 (3 – 7.25)	0.70	0.28
Duration of follow-up, median years (IQR)	0.9 (0.5 – 4.0)	0.8 (0.4 – 2.8)	1.3 (0.9 – 2.4)	0.70	0.28
Sum of HCAs at baseline, median cm (IQR)	4.0 (2.5 – 7.4)	3.3 (1.7 – 5.9)	4.4 (3.3 – 6.8)	0.78	0.63
Sum of HCAs at last scan, median cm (IQR)	4.5 (2.3 – 7.0)	7.0 (3.9 – 7.2)	5.2 (2.5 – 6.2)	0.95	0.56
Change in sum of HCA diameters, median % change (IQR)	−7.4 (-17.6 – 27.9)	29.4 (17.4 – 140.4)	−15.0 (-24.4 – 5.9)	0.52	0.04
> 10% increase in sum of HCA diameters, n (%)	7 (37%)	5 (71%)	2 (25%)	0.68	0.13

HCA, hepatocellular adenoma; HNF, hepatocyte nuclear factor. IQR, interquartile range. p-values for n (%) based on Fisher’s exact test; p-values for median (IQR) based on exact Wilcoxon tests.