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. 2023 Jun 14;18(6):e0287029. doi: 10.1371/journal.pone.0287029

Table 5. Quality of evidence assessment based on Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria.

Movement variability based on the task preformed Number of LBP patients (studies) Risk of bias (D&B scale score) Inconsistency Indirectness Imprecision Number of participants Publication bias Overall Quality of Evidence
LBP group Control group
Repeated Flexion and Extension tasks 91 (3)
Graham 2014
Mokhtarinia et al. 2016
Bauer et al. 2017
Not serious
67%
75%
83%
Not serious
Seriousb
Seriousc

10
22
59

10
22
27
Suspectedd
Very low
Lifting tasks 184 (5)
Dideriksen et al. 2014
Bauer et al. 2015
Moreno Catalá et al. 2018
Pranata et al. 2018
Fujii et al. 2022
Not serious
75%
83%
67%
67%
67%
Seriousa
Seriousb
Seriousc

17
63
30
43
31

17
31
29
29
20
Suspectedd
Very low
Gait 89 (5)
Vogt et al. 2001
Lamoth et al. 2006a
Lamoth et al. 2006b
Seay et al. 2011
Ebrahimi et al. 2017
Not serious
67%
67%
67%
67%
67%
Seriousa
Seriousb
Seriousc

34
19
12
14
10

22
14
12
14
10
Suspectedd
Very low
Sit to stand to sit (STS) task 16 (1)
Ippersiel et al. 2018
Not serious
83%
Seriousa
NA*
Seriousc

16

21
Suspectedd
Very low

GRADE: High quality: very confident that the true effect lies close to that of the estimate of the effect and further research is very unlikely to change. Moderate quality: moderately confident in the effect estimate and further research may change the estimate. Low quality: limited confident in the effect estimate and further research is very likely to have an important impact to change the estimate. Very low quality: Any estimate of effect is very uncertain.

a High level of heterogeneity; we downgrade one level due to variability in results or inconsistency between effects.

b Evidence was not directly comparable to the question of interest; we downgrade one level due to the variety of outcome measurement tools including the used motion analysis systems and the analysis metrics.

c Few participants and few events: we downgrade one level due to the wide confidence interval (CI) around the estimate of the effect (as estimated by forest plot).

dLimited number of observational studies with small sample size as well as asymmetrical distribution of observations on the funnel plot

NA* not applicable: Only one study.