Table 3.

Binding interactions of the hit compounds and reference drug with AKT 1

S/N	Compound name	Interacting residues	Conventional H-bond
1	Cynaroside	Gly159, Phe161, Gly162, Lys179, Leu181, Glu191, Glu234, and Gly294	Gly159, Gly162, Glu191, and Glu234
2	Epicatechin gallate	Leu156, Lys158, Val164, Ala177, Glu228, Ala230, Glu234, Met281, and Thr291	Lys158, Glu228, and Thr291
3	Capivasertib (reference drug)	Leu156, Phe161, Val164, Ala177, Lys179, Leu181, His194, Glu198, Met281, and Asp292	Asp292