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Binding interactions of the hit compounds and reference drug with AKT 2
| S/N | Compound name | Interacting residues | Conventional H-bond |
|---|---|---|---|
| 1 | Cynaroside | Phe163, Asn230, Glu236, Asp293, and Phe443 | Glu236, and Asn230 |
| 2 | Epicatechin gallate | Leu158, Phe163, Val166, Glu236, Lys277, and Met282 | – |
| 3 | Capivasertib (reference drug) | Leu158, Phe163, Val166, Glu279, Asp293, and Phe443 | Leu158 |
