Table 5.

ADMET profile of hit compounds and reference drug

ADMET parameters	Capivasertib	Cynaroside	Epicatechin gallate
hERG Inhibition	0.538	0.027	0.041
FDAMDD	0.922	0.031	0.55
Lipinski rule	Accepted	Rejected	Accepted
Pfizer rule	Accepted	Accepted	Accepted
GSK rule	Rejected	Rejected	Rejected
Golden triangle rule	Accepted	Accepted	Accepted
BBB	0.687	0.061	0.008
SAscore	3.256	3.924	3.608
CL	4.668	4.318	17.814
P-gp inhibitor	0.01	0.001	0.024
Bioavailability	0.55	0.17	0.55
Carcinogenicity	0.233	0.569	0.042
Nephrotoxicity	0.517	0.081	0.196