Table 2.
1H-MRS data quality.
| Baseline | N-acetylcysteine | Placebo | ANOVA | |
|---|---|---|---|---|
| Tissue fractions of dACC | ||||
| Gray matter (GM) | 0.61 (0.02) | 0.60 (0.02) | 0.60 (0.03) | F = 0.27, p = 0.76 |
| White matter (WM) | 0.26 (0.03) | 0.26 (0.03) | 0.26 (0.03) | F = 0.02, p = 0.99 |
| Cerebrospinal fluid (CSF) | 0.13 (0.03) | 0.13 (0.02) | 0.14 (0.02) | F = 0.43, p = 0.65 |
| GM:BM | 0.70 (0.03) | 0.70 (0.03) | 0.70 (0.04) | F = 0.02, p = 0.98 |
| SNR (Cr) | ||||
| Glx | 263.31 (47.51) | 261.23 (36.05) | 281.89 (43.97) | F = 2.19, p = 0.12 |
| GABA+ | 207.11 (34.29) | 205.06 (29.28) | 220.69 (31.45) | F = 2.22, p = 0.12 |
| GSH | 124.38 (16.39) | 123.37 (19.49) | 129.83 (14.40) | F = 1.18, p = 0.31 |
| Linewidth (Cr) | ||||
| Glx | 4.93 (0.87) | 4.63 (0.36) | 4.53 (0.33) | F = 3.93, p = 0.02 |
| GABA+ | 4.43 (0.66) | 4.23 (0.25) | 4.25 (0.25) | F = 2.02, p = 0.14 |
| GSH | 4.20 (0.45) | 4.06 (0.27) | 4.12 (0.31) | F = 1.07, p = 0.34 |
| Linewidth (H2O) | ||||
| Glx | 5.78 (0.40) | 5.90 (0.87) | 5.79 (0.45) | F = 0.40, p = 0.67 |
| GABA+ | 5.74 (0.43) | 5.64 (0.26) | 5.58 (0.33) | F = 1.54, p = 0.22 |
| GSH | 5.48 (0.33) | 5.35 (0.26) | 5.43 (0.38) | F = 1.13, p = 0.33 |
Baseline: Glx n = 30, GABA+ n = 31, GSH n = 27; N-acetylcysteine and placebo: Glx and GABA+ n = 31, GSH n = 28.
Glx glutamate + glutamine and secondary metabolites from PRESS (40 ms) acquisition, GABA+ GABA+ from MEGA-PRESS (68 ms) acquisition, GSH glutathione from the MEGA-PRESS (120 ms) acquisition, Tissue fractions percent of brain tissue (GM, WM, or CSF) in the dACC voxel, GM:BM brain tissue composition [GM/(GM + WM)], SNR (Cr) ratio between amplitude of Cr peak and standard deviation of detrended noise, Linewidth (Cr) FWHM of single-Lorentzian fit to Cr peak, Linewidth (H2O) FWHM of single-Lorentzian fit to H2O reference peak.
Bold values indicate statistical significance.