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. 2023 Jun 14;13:9657. doi: 10.1038/s41598-023-33915-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Lower expression of CD44 was found in tumors as compared with non-tumor tissues in patients with BLCA. (B) Correlation between expression of CD44 and survival of 406 BLCA patients based on data from Ualcan plotter. (C) CD44 transcription in subgroups of patients with BLCA, stratified based on individual cancer stages, molecular subtypes, histological subtypes (UALCAN). (D) Correlation analyses between CD44 expression and Immune checkpoint-linked genes (PD-L1, CTLA-4, CD44) in BLCA using TIMER. (*P < 0.01, **P < 0.001, ***P < 0.0001).