Figure 4.

A, Distribution of MDR pathogens through the study period. MDR pathogens included MDR and ESBL-producing GNB, MRSA, and VRE. MDR GNB definitions were based on previously published guidelines [14]. Results are presented as stacked bar charts including the proportions of MDR pathogens, non-MDR pathogens, and pathogens with unknown resistance patterns. B, Distribution of resistant pathogens through the study period, including MDR and ESBL GNB, MRSA, and VRE. MDR GNB definitions were based on previously published guidelines [14]. Results are presented as the proportion of resistant pathogens over the number of pathogens with known antibiotic susceptibilities per year. Data on bacterial drug resistance were collected after 2012; hence results are presented between 2012 and 2019. Antimicrobial resistance patterns were not available for all pathogens between 2012 and 2019. Abbreviations: BSI, bloodstream infection; ESBL, extended-spectrum beta-lactamase; MDR, multidrug-resistant; MRSA, methicillin-resistant Staphylococcus aureus; VRE, vancomycin-resistant enterococci.