TABLE 2.

Inhibitors of transporter proteins antagonizing cisplatin ototoxicity.

References	Agent	Mechanism
Thomas et al., 2013	MET	The inhibition of MET by quinine or EGTA can prevent cisplatin-induced hair cell death.
More et al., 2010	CTR1	Reduction of cisplatin trafficking into cochlear cells by intratympanic administration of copper sulfate, a substrate of the mammalian CTR1.
Ciarimboli et al., 2010	OCT2	Inhibition of OCT2 protein by cimetidine prevents cisplatin-induced ototoxicity.
Li et al., 2022b	MET or OCT	Genetically disrupting MET or OCT both partially protects hair cells from cisplatin-induced hair cell death in mouse.
Wakai et al., 2022	OCT2	Lansoprazole, a proton pump inhibitor, also can inhibit OCT2-mediated transport of CDDP.
Di et al., 2020	TRPV1	Ursolic acid inhibits the TRPV1/Ca2+/calpain-oxidative stress pathway.