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. 2023 Jun 1;4:1164057. doi: 10.3389/fragi.2023.1164057

TABLE 1.

G4 helicases involved in a wide range of cellular functions.

G4 helicase Affinity Function Comment
PIF1 G4-DNA Chisholm et al. (2012) DNA replication Paeschke et al. (2013) and telomere maintenance Paeschke et al. (2013) Cancer Wu et al. (2015)
BLM G4-DNA Cheok et al. (2005) DNA replication Rodriguez et al. (2012); Vannier et al. (2013), transcription Nguyen et al. (2014b), recombination Rodriguez et al. (2012), and telomere maintenance Vannier et al. (2013) Bloom syndrome Bharti et al. (2013)
FANCJ G4-DNA London et al. (2008); Lee et al. (2021) DNA replication Wu et al. (2009) Fanconi anemia Liu et al. (2021b)
RECQ1 G4-DNA Li et al. (2014) Transcription Popuri et al. (2014); Lu et al. (2016) and telomere maintenance Fry and Loeb. (1999)
WRN G4-DNA Crabbe et al. (2004); Wu et al. (2017) DNA replication Sarkies et al. (2012); Tang et al. (2016), transcription (Shen et al. (1998), and telomere maintenance Sarkies et al. (2012) Werner syndrome Chai et al. (2013)
DNA2 G4-DNA (Takahama et al., 2013) DNA replication Takahama et al. (2013) and telomere maintenance Lin et al. (2013b); Markiewicz-Potoczny et al. (2018); Kotsantis et al. (2020)
RTEL1 G4-DNA Vannier et al. (2012) DNA replication Wu et al. (2012), transcription Wu et al. (2012), and telomere maintenance Masuda-Sasa et al. (2008); Vannier et al. (2012) Hoyeraal–Hreidarsson syndrome Le Guen et al. (2013)
DDX11 G4-DNA van Schie et al. (2020) DNA replication Tippana et al. (2016) Warsaw breakage syndrome van Schie et al. (2020)
DDX5 G4-DNA Wu et al. (2019)/G4-RNA (Dardenne et al. (2014); Herdy et al. (2018) Transcription Wu et al. (2019) and mRNA splicing Dardenne et al. (2014)
DHX36 G4-DNA Creacy et al. (2008; Chen et al. (2015); You et al. (2017); Ribeiro de Almeida et al. (2018)/G4-RNA (Creacy et al. (2008) Transcription, mRNA polyadenylation Benhalevy et al. (2017), mRNA localization Maltby et al. (2020), mRNA degradation Tran et al. (2004), miRNA function Booy et al. (2014), translation Murat et al. (2018), and telomere maintenance Booy et al. (2012)
DDX1 G4-DNA Zhang et al. (2021)/G4-RNA Zhang et al. (2019b) IgH class switch recombination Zhang et al. (2019b)
DHX9 G4-DNA Chakraborty and Grosse. (2011)/G4-RNA Chakraborty and Grosse. (2011) Translation regulation Murat et al. (2018)
DDX3X G4-RNA Herdy et al. (2018) Transcription Herdy et al. (2018) and rRNA remodeling Penev et al. (2019)
DDX17 G4-RNA Dardenne et al. (2014); Herdy et al. (2018) Transcription Herdy et al. (2018), mRNA splicing Dardenne et al. (2014), and rRNA modeling Penev et al. (2019)
DDX21 G4-RNA McRae et al. (2017) Translation McRae et al. (2017); McRae et al. (2020) and rRNA modeling Penev et al. (2019)
DDX2 G4-RNA Wolfe et al. (2014) Translation Wolfe et al. (2014) Cancer Wolfe et al. (2014)
MOV10 G4-RNA Qureshi et al. (2012) Translation Kenny et al. (2014)
MOV10L G4-RNA Qureshi et al. (2012); Vourekas et al. (2015) piRNA biogenesis